Understanding the albumin creatinine ratio calculator — concept and principle
This calculator works out the urine albumin-to-creatinine ratio (ACR) from a spot urine sample, in mg/g and mg/mmol, and places it in the KDIGO albuminuria categories A1 to A3. People with diabetes or high blood pressure checking kidney results, and students, use it.
How it is calculated
- Creatinine to g/L: mg/dL × 0.01, or mmol/L × 0.11312 (molar mass 113.12 g/mol)
- Albumin in mg/dL × 10 = mg/L
- ACR (mg/g) = urine albumin (mg/L) ÷ urine creatinine (g/L)
- ACR (mg/mmol) = mg/g ÷ 8.84
- KDIGO: A1 under 30 mg/g (under 3 mg/mmol); A2 30–300 mg/g (3–30 mg/mmol); A3 300 mg/g or more
The principle
Healthy kidneys let very little albumin into the urine, so albumin in urine is an early sign of kidney damage. A single urine sample can be dilute or concentrated, which changes the albumin concentration. Creatinine is excreted at a fairly steady rate, so dividing albumin by creatinine corrects for concentration and approximates the daily albumin loss. KDIGO uses albuminuria categories alongside kidney function (GFR) to describe chronic kidney disease.
Worked example
Defaults: urine albumin 45 mg/L; urine creatinine 120 mg/dL.
- Creatinine = 120 × 0.01 = 1.2 g/L; albumin 45 mg/L.
- ACR = 45 ÷ 1.2 = 37.5 mg/g.
- In mg/mmol = 37.5 ÷ 8.84 = 4.2.
- 30–300 mg/g: Category A2, Moderately increased.
| Urine creatinine | Albumin/creatinine ratio (mg/g) |
|---|---|
| 30 | 150 |
| 60 | 75 |
| 90 | 50 |
| 120 | 37.5 |
| 150 | 30 |
| 180 | 25 |
| 240 | 18.8 |
How to read the result
A result in A2 or A3 should be confirmed, because exercise, fever, infection, menstruation and very high blood sugar can raise a single result. KDIGO asks for raised values to be repeated; chronic kidney disease requires abnormalities lasting more than three months. Your doctor interprets ACR together with eGFR, blood pressure and other findings.
Common mistakes
- Using albumin and creatinine from different samples.
- Mixing mg/g and mg/mmol thresholds.
- Testing after heavy exercise or during an infection.
- Treating one raised result as a diagnosis.
Frequently asked questions
What is a normal urine ACR?
Under 30 mg/g (under 3 mg/mmol) is category A1.
Why use a ratio instead of albumin alone?
The ratio corrects for how concentrated the urine sample is.
How many mg/g is 3 mg/mmol?
About 26.5 mg/g; KDIGO rounds the category boundary to 30 mg/g.
Sources: KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease, Kidney Int Suppl 2013;3(1)