Understanding the BUN creatinine ratio calculator — concept and principle
This calculator works out the ratio of blood urea nitrogen (BUN) to serum creatinine, converting from urea in mmol/L or creatinine in µmol/L if needed, and shows whether the ratio is low, in the usual range or in a prerenal pattern. Patients reading kidney tests and students use it.
How it is calculated
- BUN (mg/dL) = urea (mmol/L) × 2.8 when urea is reported
- Creatinine (mg/dL) = µmol/L ÷ 88.4 when reported in µmol/L
- Ratio = BUN (mg/dL) ÷ creatinine (mg/dL)
- Usual range about 10–20; above 20 prerenal pattern; below 10 low ratio
The principle
Both urea and creatinine are waste products cleared by the kidneys, but they are handled differently. Creatinine is filtered and hardly reabsorbed, while urea is partly reabsorbed, more so when blood flow to the kidneys falls, for example with dehydration, bleeding or heart failure. Then BUN rises more than creatinine and the ratio goes above 20. Bleeding in the stomach or bowel, a high-protein diet, steroids and catabolic illness also raise urea production. A low ratio is seen with low protein intake, liver disease, pregnancy and after dialysis.
Worked example
Defaults: BUN 28 mg/dL; creatinine 1.1 mg/dL.
- BUN = 28 mg/dL; creatinine = 1.1 mg/dL.
- Ratio = 28 ÷ 1.1 = 25.5.
- Above 20: Above 20 – prerenal pattern.
| Serum creatinine | BUN/creatinine ratio |
|---|---|
| 0.275 | 101.8 |
| 0.55 | 50.9 |
| 0.825 | 33.9 |
| 1.1 | 25.5 |
| 1.38 | 20.4 |
| 1.65 | 17 |
| 2.2 | 12.7 |
How to read the result
The ratio is only a clue and must be read with the absolute values, the history and other tests. A high ratio with normal BUN and creatinine means little on its own, while a high ratio with rising values may suggest reduced kidney perfusion. Your doctor will interpret the pattern.
Common mistakes
- Using urea in mg/dL as if it were BUN; urea mass is about 2.14 times BUN.
- Mixing units without converting.
- Reading the ratio without the absolute values.
- Ignoring recent diet, bleeding or medicines.
Frequently asked questions
What is a normal BUN to creatinine ratio?
About 10 to 20 in common clinical references.
What does a ratio above 20 mean?
Often reduced blood flow to the kidneys, such as dehydration, but other causes exist.
How do I convert urea mmol/L to BUN?
Multiply by 2.8 to get BUN in mg/dL.
Sources: Standard clinical reference values for the BUN:creatinine ratio; conversion factors urea mmol/L × 2.8 = BUN mg/dL and 88.4 µmol/L creatinine = 1 mg/dL