Lille Score Calculator (steroid response in severe alcohol-related hepatitis)

Understanding the Lille score calculator — concept and principle

The Lille score is calculated after 7 days of corticosteroid treatment for severe alcohol-related hepatitis. It shows whether the liver is responding, which helps doctors decide whether to continue steroids or stop them and avoid side effects without benefit.

Day 7 of steroids: with the default inputs the result is Lille 0.166 (below 0.45 → responder).

How it is calculated

R = 3.19 − 0.101 × age + 0.147 × albumin day 0 (g/L) + 0.0165 × (bilirubin day 0 − day 7, µmol/L) − 0.206 × renal insufficiency − 0.0065 × bilirubin day 0 (µmol/L) − 0.0096 × prothrombin time (s)

Lille score = e^(−R) ÷ (1 + e^(−R))

Renal insufficiency = 1 if creatinine is above 1.3 mg/dL (115 µmol/L), otherwise 0.
Bilirubin in mg/dL is multiplied by 17.1; albumin in g/dL by 10.
0.45 or more = non-responder.

The principle

Louvet and colleagues (2007) found that the early fall in bilirubin during the first week of steroids was the strongest sign of response, alongside age, kidney function, albumin and clotting. A logistic model combines them into a probability-like score between 0 and 1. A higher score means a poorer outlook despite treatment.

Worked example

Default inputs: age 50, albumin 28 g/L, bilirubin 250 µmol/L on day 0 and 180 on day 7, no renal insufficiency, PT 18 s.

Bilirubin change = 180 − 250 = −70 µmol/L.
R = 3.19 − 5.05 + 4.116 + 1.155 − 0 − 1.625 − 0.173 = 1.613.
Lille = e^(−1.613) ÷ (1 + e^(−1.613)) = 0.199 ÷ 1.199 = 0.166.
Below 0.45 → Responder.

Each point is the calculator re-run with only “Albumin on day 0” changed; the gold point is the default example. Change the inputs above and this chart follows your numbers.

Albumin on day 0	Lille score
7	0.814
14	0.609
21	0.358
28	0.166
35	0.066
42	0.025
56	0.003

How to read the result

Where does your result fall?

In the original cohort, non-responders (0.45 or more) had about 25% six-month survival compared with about 85% for responders, and stopping steroids is usually considered. A low score supports continuing the planned course. Abstinence from alcohol remains the key long-term factor.

Common mistakes

Entering bilirubin in mg/dL while the unit is set to µmol/L.
Using day-7 values from a different day.
Using the score in patients not treated with steroids.

Keep in mind: This is a decision aid for clinicians, not a diagnosis or treatment advice. Alcohol-related hepatitis needs specialist care.

Frequently asked questions

When is the Lille score calculated?

On day 7 of steroid treatment; some studies show day 4 gives similar information.

What does a high Lille score mean?

The liver is not responding well to steroids, and the team will usually reconsider treatment.

How does it relate to Maddrey's score?

Maddrey's discriminant function decides who is severe enough for steroids; Lille judges response after a week.

Sources: Louvet A, Naveau S, Abdelnour M, et al., "The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids", Hepatology 2007;45(6):1348–1354

Checked 9 Nov 2026. Louvet A, Naveau S, Abdelnour M, et al., “The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids”, Hepatology 2007;45(6):1348–1354 — coefficients, renal-insufficiency definition and 0.45 cut-off as reproduced by the Lille Model article (Wikipedia) and QxMD; survival figures from QxMD.

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