Understanding the PRAL (dietary acid load) calculator — concept and principle
PRAL, the potential renal acid load, estimates how much acid or base your diet leaves for the kidneys to excrete each day. You enter daily intakes of protein, phosphorus, potassium, magnesium and calcium, and the calculator returns PRAL in milliequivalents per day (mEq/day) and labels the diet as acid-forming or base-forming. Researchers use it to study diet, bone health, kidney stones and kidney disease.
How it is calculated
PRAL (mEq/day) = 0.4888 × protein (g) + 0.0366 × phosphorus (mg) − 0.0205 × potassium (mg) − 0.0125 × calcium (mg) − 0.0263 × magnesium (mg)
Protein and phosphorus raise PRAL (acid side); potassium, calcium and magnesium lower it (base side). A positive result is acid-forming, a negative result is base-forming. Use daily totals: protein in grams, minerals in milligrams.
The principle
Remer and Manz built PRAL from the main ions that create or neutralise acid after digestion. Protein contains sulfur amino acids (methionine and cysteine) that are metabolised to sulfuric acid, and phosphorus contributes phosphate. Potassium, magnesium and calcium in foods such as fruit and vegetables usually come with organic anions (for example citrate) that are metabolised to bicarbonate, a base. Each coefficient combines the ion's charge, molar mass and average intestinal absorption. The model was validated against measured urinary net acid excretion in healthy adults.
Worked example
- Inputs: protein 90 g, phosphorus 1,300 mg, potassium 3,000 mg, magnesium 350 mg, calcium 900 mg.
- Acid terms: 0.4888 × 90 = 43.99; 0.0366 × 1,300 = 47.58. Sum = 91.57.
- Base terms: 0.0205 × 3,000 = 61.50; 0.0125 × 900 = 11.25; 0.0263 × 350 = 9.21. Sum = 81.96.
- PRAL = 91.57 − 81.96 = 9.62 mEq/day, a positive value, so the diet is classed as acid-forming.
| Potassium (mg) | PRAL (mEq/day) |
|---|---|
| 750 | 55.74 |
| 1,500 | 40.37 |
| 2,250 | 24.99 |
| 3,000 | 9.62 |
| 3,750 | -5.76 |
| 4,500 | -21.13 |
| 6,000 | -51.88 |
How to read the result
Values near zero mean acid and base sources roughly balance. Diets heavy in meat, cheese and grains and low in produce give positive values; plant-heavy diets often fall below zero. The number is not your blood pH: healthy kidneys and lungs keep blood pH in a tight range whatever you eat. PRAL is most useful for comparing your own diet before and after a change.
Common mistakes
- Entering phosphorus or potassium in grams instead of milligrams, which shifts the result by a factor of 1,000.
- Reading a positive PRAL as a sign of disease or of acidic blood.
Frequently asked questions
Are foods that taste sour, like lemons, acid-forming?
No. Lemons are rich in potassium and citrate, which are metabolised to base, so their PRAL is negative despite the sour taste.
Is a lower PRAL always better?
Not necessarily. A very negative score can come from too little protein; overall diet quality matters more.
Sources: Remer T, Manz F. Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc 1995;95(7):791–797.